Pretreatment anemia status and elevated PLR affect the prognosis of locally advanced cervical squamous cell carcinoma patients treated with concurrent chemoradiotherapy

Objective: To assess the prognostic value of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), and systemic immune-inflammation index (SII) in locally advanced cervical squamous cell carcinoma (LACSC) treated with concurrent chemoradiotherapy (CCRT) regimens. Methods: The contribution immune inflammatory response markers (NLR, PLR, LMR, SII), cells (lymphocytes, neutrophils, monocytes, platelets), hematocrit predicting outcomes treatment LACSC patients was examined using Kaplan-Meier univariate survival analysis method. Variables that were significant for included multivariate regression to confirm independent factors affecting patients. Results: Univariate showed age (p = 0.024), PLR 0.007), NLR 0.089), LMR 0.021), SII 0.087), Hb 0.004) all OS (over survival). Multivariate revealed 0.066) 0.045) before risk studied population. Moreover, these two significantly correlated (correlation coefficient Rs –0.426, p 0.000). Conclusions: results suggested elevated anaemia are likely have poorer prognoses who initially received radical CCRT. pre-treatment anemia status may exacerbate effects PLR.